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The hepatic clearance (C14,S) of C-14-labeled GAG (per kg body weight) was calculated to be 0.19 +/- 0.04 ml/min. The excretion of metabolites in bile and urine showed both glucuronide and sulfate conjugates in the bile but only glucuronide conjugates in the urine. The biliary elimination of both metabolites was competitively inhibited by unlabeled GAG but not by heparin. The plasma C-14-labeled GAG was shown to be cleared by two distinct mechanisms. One was heparin-sensitive and the other was heparin-insensitive. Heparin inhibited the clearance of C-14-labeled GAG by acting as a competitive inhibitor of the hepatic clearance of both glucuronide and sulfate conjugates. - 1 5 1 . W h i c h i s t h e n e a r e s t t o - 2 / 1 1 ? ( a ) l ( b ) - 1 ( c ) 1 b L e t t = - 6 5 . 1 - - 6 5 . 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